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AS01 is a liposome-based Adjuvant System containing the immunoenhancers MPL (3- Odesacyl- 4'-monophosphoryl lipid A) and QS- 21 (a saponin molecule purified from the bark extract of Quillaja saponaria Molina tree). Pfs230D1M and EPA were chemically crosslinked to form Pfs230D1M-EPA conjugate.There are two formulations in the AS01 family: AS01B Adjuvant System and AS01E Adjuvant System. AS01B will be mixed directly with the vialed conjugated Pfs230D1M for a final formulation of either 13mcg conjugated Pfs230D1M, 10mcg conjugated EPA in AS01 (25mcg MPL 25mcg QS21 liposomal formulation) for Arms 2a, 3a or 40mcg conjugated Pfs230D1M, 31mcg conjugated EPA in AS01 for Arms 2b, 3b, 3c, 3d.

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. They want to test vaccines to block malaria transmission in adults in Mali.

For the rest of the months, they will have 1 monthly visit. They get the vaccine through an injection in the upper arm.

This occurs at their first visit, then 1 month later, and then 5 months later.

While AS01B contains 50 microgram of MPL and 50 microgram of QS-21 per one human dose, AS01E contains half the quantity of each immunoenhancer, i.e. For this study, the AS01B adjuvant will be used at a diluted concentration similar to the concentration of AS01E. The fractional dose (Dose #3) in Arm 3d will be 1/5th of the Pfs230D1M dose in AS01 (final formulation of 8mcg conjugated Pfs25M, 2mcg conjugated EPA in AS01 [5mcg MPL 5mcg QS21 liposomal formulation]).

Pfs230 is a malaria parasite antigen expressed in gametocytes and on the surface of emerging gametes in the mosquito host and is also a TBV target. AS01 is a liposome-based Adjuvant System containing the immunoenhancers MPL (3- Odesacyl- 4'-monophosphoryl lipid A) and QS- 21 (a saponin molecule purified from the bark extract of Quillaja saponaria Molina tree). Pfs230D1M and EPA were chemically crosslinked to form Pfs230D1M-EPA conjugate.

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